Clinical Value of Ezrin Expression in Primary Osteosarcoma
نویسندگان
چکیده
منابع مشابه
Ezrin and moesin expression in canine and feline osteosarcoma.
Biological features of canine osteosarcomas (OS) differ markedly from those found in feline and resemble more human osteosarcomas, in particular for their high rate of metastasis and poor prognosis. Ezrin, radixin and moesin are members of the ERM protein family and link the actin cytoskeleton with the cell membrane. Ezrin and moesin have been shown to be of prognostic significance in tumor pro...
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PURPOSE The aim of this study was to investigate the clinical significance of circulating tumor cells (CTCs) in the peripheral blood of an osteosarcoma and the Ezrin gene expressed in CTCs. PATIENTS AND METHODS CTC enrichment was done with CanPatrol™ CTC enrichment technique in 41 patients with osteosarcoma. The characterization of CTCs was performed using a multiple messenger RNA in situ ana...
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PURPOSE To determine the prognostic value of the expression of Ezrin, CD44 and Six1 genes in osteosarcoma tissues of Chinese patients. METHODS Fluorescent quantitative real-time PCR was applied to study the mRNA levels of Ezrin, CD44 and Six1 genes in 32 osteosarcoma patient samples and 10 adjacent normal tissues and MG63 osteosarcoma cell lines. The analysis of relationships between pulmonar...
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Osteosarcoma is one primary bone tumor with high risk of blood borne metastasis, thus causing aggravation and patient death. The study of molecular mechanism underlying metastasis of osteosarcoma thus may help to relieve the threat of osteosarcoma. Sclareol has been found to have anti-tumor effects in leukemia, colorectal cancer and osteosarcoma, but with unclear functional mechanism so far. Th...
متن کاملCorrelation between chemotherapy resistance in osteosarcoma patients and PAK5 and Ezrin gene expression
The correlation between PAK5 (P21-activated kinase 5) and Ezrin gene expression and chemotherapy resistance of osteosarcoma patients was investigated. The cisplatin (CDDP)-resistance model of osteosarcoma cells SOSP-9607/CDDP was established to detect the cell growth curve. Methyl thiazolyl tetrazolium (MTT) assay was used to detect the drug resistance of cells to chemotherapy drugs. Transwell ...
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ژورنال
عنوان ژورنال: Cancer Research and Treatment
سال: 2009
ISSN: 1598-2998
DOI: 10.4143/crt.2009.41.3.138